N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt

Base Information

Chemical Name:N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt
CAS No.:126371-47-9
Molecular Formula:C₂₂H₂₅N₄O₁₀S*3Li
Molecular Weight:558.35
Hs Code.:

N-<2-<<2-<Bis(carboxymethyl)amino>ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt

Chemical Property:

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Technology Process of N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt

There total 5 articles about N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-43-6,84932-15-0
diethylenetriaminopentaacetic acid

: 126371-47-9,145900-10-3
N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / SOCl₂ / 16 h

2: 1) LDA / 1) THF, -78 deg C, 20 min, 2) HMPA, 12 h, -78 deg C -> 25 deg C

3: 1) 97percent H₂SO₄, conc. HNO₃, 2) SOCl₂ / 1) 0 deg C, 3 h, 2) 0 deg C, 14 h

4: H₂ / 30percent Pd/C / methanol / 3 h / 3102.9 Torr

5: 100 percent / LiOH / methanol; H₂O / 3 h

6: 99 percent / methanol; CHCl₃ / 1 h

With lithium hydroxide; thionyl chloride; sulfuric acid; hydrogen; nitric acid; lithium diisopropyl amide; palladium on activated charcoal; In methanol; chloroform; water;
DOI:10.1021/jo00296a057

Reference yield:

: 96121-82-3
methyl 5,8,11,-tris(2-methoxy-2-oxoethyl)-3-oxo-2-oxa-5,8,11-triazatridecan-13-oate

: 126371-47-9,145900-10-3
N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt

Guidance literature:: Multi-step reaction with 5 steps

1: 1) LDA / 1) THF, -78 deg C, 20 min, 2) HMPA, 12 h, -78 deg C -> 25 deg C

2: 1) 97percent H₂SO₄, conc. HNO₃, 2) SOCl₂ / 1) 0 deg C, 3 h, 2) 0 deg C, 14 h

3: H₂ / 30percent Pd/C / methanol / 3 h / 3102.9 Torr

4: 100 percent / LiOH / methanol; H₂O / 3 h

5: 99 percent / methanol; CHCl₃ / 1 h

With lithium hydroxide; thionyl chloride; sulfuric acid; hydrogen; nitric acid; lithium diisopropyl amide; palladium on activated charcoal; In methanol; chloroform; water;
DOI:10.1021/jo00296a057

Reference yield:

: 126216-31-7
N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-DL-phenylalanine Pentamethyl Ester

: 126371-47-9,145900-10-3
N-<2-<<2-ethyl>(carboxymethyl)amino>ethyl>-N-(carboxymethyl)-4-isothiocyanato-DL-phenylalanine Trilithium Salt

Guidance literature:: Multi-step reaction with 4 steps

1: 1) 97percent H₂SO₄, conc. HNO₃, 2) SOCl₂ / 1) 0 deg C, 3 h, 2) 0 deg C, 14 h

2: H₂ / 30percent Pd/C / methanol / 3 h / 3102.9 Torr

3: 100 percent / LiOH / methanol; H₂O / 3 h

4: 99 percent / methanol; CHCl₃ / 1 h

With lithium hydroxide; thionyl chloride; sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In methanol; chloroform; water;
DOI:10.1021/jo00296a057