N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide

Base Information

Chemical Name:N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide
CAS No.:1036403-52-7
Molecular Formula:C₂₄H₂₃FN₄O₃
Molecular Weight:434.47
Hs Code.:

Synonyms:

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Chemical Property of N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide

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Technology Process of N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide

There total 6 articles about N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036403-18-5
8-(3-amino-4-fluorobenzyl)pyrido[2,3-d]pyridazin-5(6H)-one

: 1036403-52-7
N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; platinum on carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C / 2585.81 Torr / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With hydrogenchloride; platinum on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 1036403-14-1
2-fluoro-5-[(5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

: 1036403-52-7
N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; potassium hydroxide / 1.17 h / -10 - 65 °C / Inert atmosphere

2.1: hydrogenchloride; platinum on carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With hydrogenchloride; platinum on carbon; hydrogen; bromine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 605-38-9
dimethyl 2,3-pyridinedicarboxylate

: 1036403-52-7
N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-4-oxo-4-phenylbutanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine; magnesium / diethyl ether / Reflux; Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: hydrazine / ethanol / 5 h / 20 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / N,N-dimethyl-formamide / 5 h / 100 °C / 3102.97 Torr / Inert atmosphere

4.1: ammonia / methanol / 70 °C / Inert atmosphere

5.1: bromine; potassium hydroxide / 1.17 h / -10 - 65 °C / Inert atmosphere

6.1: hydrogenchloride; platinum on carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C / 2585.81 Torr / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

7.2: 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; ammonia; hydrogen; bromine; iodine; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; hydrazine; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021