C₁₇H₁₈F₃N₅O₃

Base Information

Chemical Name:C₁₇H₁₈F₃N₅O₃
CAS No.:1294041-33-0
Molecular Formula:C₁₇H₁₈F₃N₅O₃
Molecular Weight:397.357
Hs Code.:

C<sub>17</sub>H<sub>18</sub>F<sub>3</sub>N<sub>5</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₁₇H₁₈F₃N₅O₃

Chemical Property:

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Technology Process of C₁₇H₁₈F₃N₅O₃

There total 7 articles about C₁₇H₁₈F₃N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293995-80-8
(5-boc-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazin-3-yl)methyl acetate

: 1294041-33-0
C₁₇H₁₈F₃N₅O₃

Guidance literature:: Multi-step reaction with 6 steps

1: water; lithium hydroxide / methanol / 2 h / 20 °C

2: iodine; potassium carbonate / 3 h / 50 °C / Inert atmosphere

3: Reflux

4: trifluoroacetic acid / dichloromethane

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

6: trifluoroacetic acid / dichloromethane

With water; iodine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.086

Reference yield:

: 1293995-77-3
C₁₃H₂₀N₄O₄

: 1294041-33-0
C₁₇H₁₈F₃N₅O₃

Guidance literature:: Multi-step reaction with 7 steps

1: dimethyl sulfoxide / 150 °C

2: water; lithium hydroxide / methanol / 2 h / 20 °C

3: iodine; potassium carbonate / 3 h / 50 °C / Inert atmosphere

4: Reflux

5: trifluoroacetic acid / dichloromethane

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

7: trifluoroacetic acid / dichloromethane

With water; iodine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.01.086

Reference yield:

: 1251002-72-8
tert-butyl 6,7-dihydro-3-(hydroxymethyl)-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate

: 1294041-33-0
C₁₇H₁₈F₃N₅O₃

Guidance literature:: Multi-step reaction with 5 steps

1: iodine; potassium carbonate / 3 h / 50 °C / Inert atmosphere

2: Reflux

3: trifluoroacetic acid / dichloromethane

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

5: trifluoroacetic acid / dichloromethane

With iodine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2011.01.086