Technology Process of 2-(3,4-diamino-5-chloro-2-methoxyphenyl)-5-methyl-4-(3-pyridyl)imidazole
There total 8 articles about 2-(3,4-diamino-5-chloro-2-methoxyphenyl)-5-methyl-4-(3-pyridyl)imidazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; iron; ammonium chloride;
In
ethanol;
for 2h;
Yield given;
Heating;
DOI:10.1248/cpb.42.560
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium acetate / acetic acid / 0.25 h / 100 °C
2: 59.9 percent / P(OEt)3 / dimethylformamide / 80 °C
3: 63.2 percent / 6N aq. HCl / 9 h / 85 - 90 °C
4: Fe, NH4Cl, H2O / ethanol / 2 h / Heating
With
ammonium acetate; hydrogenchloride; water; iron; ammonium chloride; triethyl phosphite;
In
ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.560
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 93.8 percent / HNO3 fuming / 0.17 h / -35 - -30 °C
2: LiAlH4 / tetrahydrofuran / 2 h / -30 °C
3: 84 percent / MnO2 / ethyl acetate / 6 h / Heating
4: ammonium acetate / acetic acid / 0.25 h / 100 °C
5: 59.9 percent / P(OEt)3 / dimethylformamide / 80 °C
6: 63.2 percent / 6N aq. HCl / 9 h / 85 - 90 °C
7: Fe, NH4Cl, H2O / ethanol / 2 h / Heating
With
ammonium acetate; hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; water; nitric acid; iron; ammonium chloride; triethyl phosphite;
In
tetrahydrofuran; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.560