Technology Process of 12,12-dimethyl-aplog-1
There total 16 articles about 12,12-dimethyl-aplog-1 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C43H56O9;
With
2,4,6-trichlorobenzoyl chloride; triethylamine;
In
toluene;
at 20 ℃;
for 3h;
With
dmap;
In
toluene;
at 20 ℃;
for 6h;
With
palladium 10% on activated carbon; hydrogen;
In
methanol; chloroform;
at 20 ℃;
for 5h;
DOI:10.1271/bbb.110130
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine; pyridine hydrogenfluoride / tetrahydrofuran / 15 h / 0 - 20 °C
2.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 3 h / 20 °C
2.2: 6 h / 20 °C
2.3: 5 h / 20 °C
With
pyridine; 2,4,6-trichlorobenzoyl chloride; pyridine hydrogenfluoride; triethylamine;
In
tetrahydrofuran; toluene;
DOI:10.1271/bbb.110130
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 2 h / 20 °C
1.2: 2 h / 50 °C
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 20 °C
3.1: 1H-imidazole / tetrahydrofuran / 4 h / 20 °C
4.1: sodium periodate; potassium permanganate; tert-butyl alcohol / 1 h / 20 °C / pH 7.2 / aq. phosphate buffer; Inert atmosphere
5.1: pyridine; pyridine hydrogenfluoride / tetrahydrofuran / 15 h / 0 - 20 °C
6.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 3 h / 20 °C
6.2: 6 h / 20 °C
6.3: 5 h / 20 °C
With
pyridine; 1H-imidazole; potassium permanganate; sodium periodate; 2,4,6-trichlorobenzoyl chloride; pyridine hydrogenfluoride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tert-butyl alcohol;
In
tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1271/bbb.110130
