N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Base Information

Chemical Name:N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide
CAS No.:1354558-60-3
Molecular Formula:C₃₂H₂₆Cl₂N₂O₂
Molecular Weight:541.477
Hs Code.:

N<sub>1</sub>,N<sub>2</sub>-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

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Chemical Property of N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

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Technology Process of N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

There total 10 articles about N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354558-57-8
N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

: 1354558-60-3
N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Guidance literature:: With thionyl chloride; In toluene; at 90 ℃; for 16h;
DOI:10.1039/c1ob06780j

Reference yield:

: 7-phenyl-2,3-dihydro-1H-inden-1-one

: 1354558-60-3
N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2.1: Amberlyst 15 / hexane / 3 h / 0 - 20 °C / Reflux

3.1: C₃₈H₄₂ClMnN₂O₄; 4-methylmorpholine N-oxide / dichloromethane / 0.25 h / -78 °C

3.2: -78 °C

4.1: sodium azide; ammonium chloride / ethanol; water / 2 h / Reflux

5.1: palladium 10% on activated carbon; hydrogen / methanol / 0.33 h

6.1: acetic acid / tetrahydrofuran / 16 h / 90 °C

7.1: thionyl chloride / toluene / 16 h / 90 °C

With sodium tetrahydroborate; thionyl chloride; sodium azide; palladium 10% on activated carbon; C₃₈H₄₂ClMnN₂O₄; hydrogen; ammonium chloride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene;
DOI:10.1039/c1ob06780j

Reference yield:

: 868374-23-6
3-oxo-2,3-dihydro-1H-inden-4-yl trifluoromethanesulfonate

: 1354558-60-3
N₁,N₂-bis((1R,2R)-2-chloro-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

3.1: Amberlyst 15 / hexane / 3 h / 0 - 20 °C / Reflux

4.1: C₃₈H₄₂ClMnN₂O₄; 4-methylmorpholine N-oxide / dichloromethane / 0.25 h / -78 °C

4.2: -78 °C

5.1: sodium azide; ammonium chloride / ethanol; water / 2 h / Reflux

6.1: palladium 10% on activated carbon; hydrogen / methanol / 0.33 h

7.1: acetic acid / tetrahydrofuran / 16 h / 90 °C

8.1: thionyl chloride / toluene / 16 h / 90 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium azide; palladium 10% on activated carbon; C₃₈H₄₂ClMnN₂O₄; hydrogen; sodium carbonate; ammonium chloride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene;
DOI:10.1039/c1ob06780j