Technology Process of 1α,20,24-trihydroxyvitamin D3
There total 3 articles about 1α,20,24-trihydroxyvitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
20,24-dihydroxyvitamin D3;
With
ethylenediaminetetraacetic acid; dioleoylphosphatidylcholine; sodium chloride; D,L-dithiothreitol;
In
aq. buffer;
pH=7.4;
Sonication;
With
glucose-6-phosphate dehydrogenase; ethylenediaminetetraacetic acid; glucose-6-phosphate; mouse adrenodoxin; human adrenodoxin reductase; mouse CYP27B1; NADPH; sodium chloride; D,L-dithiothreitol;
In
aq. buffer;
at 25 ℃;
for 1h;
pH=7.4;
DOI:10.1124/dmd.113.050955
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: rat CYP24A1 / Enzymatic reaction
2.1: dioleoylphosphatidylcholine; sodium chloride; D,L-dithiothreitol; ethylenediaminetetraacetic acid / aq. buffer / pH 7.4 / Sonication
2.2: 3407 / 1 h / 25 °C / pH 7.4
With
ethylenediaminetetraacetic acid; rat CYP24A1; dioleoylphosphatidylcholine; sodium chloride; D,L-dithiothreitol;
In
aq. buffer;
DOI:10.1124/dmd.113.050955
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: CYP11A1; heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin / Enzymatic reaction
2.1: rat CYP24A1 / Enzymatic reaction
3.1: dioleoylphosphatidylcholine; sodium chloride; D,L-dithiothreitol; ethylenediaminetetraacetic acid / aq. buffer / pH 7.4 / Sonication
3.2: 3407 / 1 h / 25 °C / pH 7.4
With
ethylenediaminetetraacetic acid; CYP11A1; rat CYP24A1; dioleoylphosphatidylcholine; sodium chloride; D,L-dithiothreitol; heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin;
In
aq. buffer;
DOI:10.1124/dmd.113.050955
