tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

Base Information

Chemical Name:tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate
CAS No.:1361407-80-8
Molecular Formula:C₄₁H₅₃N₃O₁₁S
Molecular Weight:795.951
Hs Code.:

tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

Synonyms:

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Chemical Property of tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

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Technology Process of tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

There total 1 articles about tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361407-79-5
tert-butyl (2S,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-(3-hydroxypropyl)-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

: 245365-64-4
N-benzyloxycarbonyl-2-nitrobenzenesulfonamide

: C₄₁H₅₃N₃O₁₁S

: 1361407-80-8
tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃; Inert atmosphere;
DOI:10.1021/jm2016914

Reference yield:

: 1361407-80-8
tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

: C₃₅H₅₀N₂O₇

: 1361407-81-9
tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)-amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

Guidance literature:: With potassium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm2016914

Reference yield:

: 1361407-80-8
tert-butyl (2S,5R,3E)-2-{3-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-3,4-dimethylhex-3-enoate

: C₂₆H₃₄N₂O₅

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 3 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium carbonate; thiophenol; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2016914