-7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid

Base Information

Chemical Name:-7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid
CAS No.:146953-18-6
Molecular Formula:C₃₂H₄₂N₄O₆
Molecular Weight:578.709
Hs Code.:

<R-(R*,R*)>-7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid

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Chemical Property of -7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid

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Technology Process of -7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid

There total 7 articles about -7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96551-27-8
α-methyl-(R)-tryptophan methyl ester

: 146953-18-6
-7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: 99 percent / LiOH / dioxane; H₂O / 24 h / Ambient temperature

3: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et₃N / 1) ethyl acetate, rt, 2 h, 2) overnight

4: 98 percent / H₂ / 20percent Pd/C / methanol / 4 h

5: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight

6: LiOH / dioxane; H₂O / 3 h / Ambient temperature

With lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1016/S0040-4020(01)86257-8

Reference yield:

: 146953-09-5
α-methyl-N-<(phenylmethoxy)carbonyl>-D-tryptophan

: 146953-18-6
-7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et₃N / 1) ethyl acetate, rt, 2 h, 2) overnight

2: 98 percent / H₂ / 20percent Pd/C / methanol / 4 h

3: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight

4: LiOH / dioxane; H₂O / 3 h / Ambient temperature

With lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; water;
DOI:10.1016/S0040-4020(01)86257-8

Reference yield:

: 141971-07-5
methyl α-methyl-N-<(phenylmethoxy)carbonyl>-D-tryptophanate

: 146953-18-6
-7-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / LiOH / dioxane; H₂O / 24 h / Ambient temperature

2: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et₃N / 1) ethyl acetate, rt, 2 h, 2) overnight

3: 98 percent / H₂ / 20percent Pd/C / methanol / 4 h

4: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight

5: LiOH / dioxane; H₂O / 3 h / Ambient temperature

With lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; water;
DOI:10.1016/S0040-4020(01)86257-8