4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

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Chemical Name:4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran
CAS No.:79691-20-6
Molecular Formula:C₃₂H₄₉FO₄Si
Molecular Weight:544.823
Hs Code.:

4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

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Chemical Property of 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

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Technology Process of 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

There total 3 articles about 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 79691-19-3,135413-68-2
4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-<(tetrahydropyran-2-yl)oxy>-3,4,5,6-tetrahydro-2H-pyran

: (4R,6R)-6-{2-[(1S,2S,6R,8S,8aR)-8-(4-Fluoro-benzyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl]-ethyl}-tetrahydro-pyran-2,4-diol

: 79691-20-6,135413-69-3
4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: With water; pyridinium p-toluenesulfonate; acetic acid; In tetrahydrofuran; for 65h; Ambient temperature;
DOI:10.1021/jm00112a024

Reference yield:

: 79691-14-8,83348-89-4
4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<1,2,6,7,8,8a(S)-hexahydro-8(S)-hydroxy-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-<(tetrahydropyran-2-yl)oxy>-3,4,5,6-tetrahydro-2H-pyran

: 79691-20-6,135413-69-3
4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, RT, 2.) THF, DMF, reflux, 18 h

2: 32 percent / pyridinium tosylate (PPTS), acetic acid, H₂O / tetrahydrofuran / 65 h / Ambient temperature

With water; pyridinium p-toluenesulfonate; sodium hydride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm00112a024

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 79691-20-6,135413-69-3
4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-<(4-fluorobenzyl)oxy>-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, RT, 2.) THF, DMF, reflux, 18 h

2: 32 percent / pyridinium tosylate (PPTS), acetic acid, H₂O / tetrahydrofuran / 65 h / Ambient temperature

With water; pyridinium p-toluenesulfonate; sodium hydride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm00112a024