C₁₉H₁₇N₃O₃

Base Information

• Chemical Name: C₁₉H₁₇N₃O₃
• CAS No.: 1236303-18-6
• Molecular Formula: C₁₉H₁₇N₃O₃
• Molecular Weight: 335.362
• Mol file: 1236303-18-6.mol

Synonyms:

Chemical Property of C₁₉H₁₇N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇N₃O₃

There total 9 articles about C₁₉H₁₇N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H15N3O3 (1236303-34-6) + propargyl bromide (106-96-7) → C19H17N3O3 (1236303-39-1) + C19H17N3O3 (1236303-18-6)

Guidance literature:

C₁₆H₁₅N₃O₃; With potassium carbonate; In water; toluene; at 0 ℃; for 0.166667h; Inert atmosphere;

With tetrabutylammomium bromide; lithium bromide; In water; toluene; at 20 ℃; for 0.166667h; Inert atmosphere;

propargyl bromide; In water; toluene; at 80 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/asia.201000073

Reference yield:

2-chloro-8-ethyl-4-methoxy-5H-pyrano[4,3-d]pyrimidine (848891-83-8) → C19H17N3O3 (1236303-39-1) + C19H17N3O3 (1236303-18-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / 5 h / 90 °C / 6965.99 Torr / Inert atmosphere

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane / 2 h / Inert atmosphere

5.1: chloro-trimethyl-silane; water; sodium iodide / acetonitrile / 65 °C / Darkness; Inert atmosphere

6.1: potassium carbonate / water; toluene / 0.17 h / 0 °C / Inert atmosphere

6.2: 0.17 h / 20 °C / Inert atmosphere

6.3: 1.5 h / 80 °C / Inert atmosphere

With chloro-trimethyl-silane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;

DOI:10.1002/asia.201000073

Reference yield:

methyl 8-ethyl-4-methoxy-5H-pyrano[4,3-d]pyrimidine-2-carboxylate (1236303-21-1) → C19H17N3O3 (1236303-39-1) + C19H17N3O3 (1236303-18-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dichloromethane / 2 h / Inert atmosphere

4.1: chloro-trimethyl-silane; water; sodium iodide / acetonitrile / 65 °C / Darkness; Inert atmosphere

5.1: potassium carbonate / water; toluene / 0.17 h / 0 °C / Inert atmosphere

5.2: 0.17 h / 20 °C / Inert atmosphere

5.3: 1.5 h / 80 °C / Inert atmosphere

With chloro-trimethyl-silane; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;

DOI:10.1002/asia.201000073

upstream raw materials:

2-chloro-8-ethyl-4-methoxy-5H-pyrano[4,3-d]pyrimidine

C₁₀H₁₀N₂O₄

C₁₆H₁₅N₃O₃

propargyl bromide