C₂₀H₂₀INO₃

Base Information

• Chemical Name: C₂₀H₂₀INO₃
• CAS No.: 1217549-19-3
• Molecular Formula: C₂₀H₂₀INO₃
• Molecular Weight: 449.288
• Mol file: 1217549-19-3.mol

Synonyms:

Chemical Property of C₂₀H₂₀INO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₀INO₃

There total 4 articles about C₂₀H₂₀INO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromomethyl-4-iodobenzene (16004-15-2) → C20H20INO3 (1217549-19-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 1 h / 0 - 25 °C

1.3: pH 4 / Cooling with ice

2.1: sulfuric acid / 16 h / Reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.1: sodium hydroxide / methanol / 6 h / Reflux

With sulfuric acid; sodium hydride; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.1615

Reference yield:

1-(p-iodobenzyl)-5-methoxy-2-methyl-3-indoleacetic acid (1217549-14-8) → C20H20INO3 (1217549-19-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 16 h / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3: sodium hydroxide / methanol / 6 h / Reflux

With sulfuric acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;

DOI:10.1002/jlcr.1615

Reference yield:

C21H22INO3 (1217549-18-2) → C20H20INO3 (1217549-19-3)

Guidance literature:

With sodium hydroxide; In methanol; for 6h; Reflux;

DOI:10.1002/jlcr.1615

upstream raw materials:

1-(p-iodobenzyl)-5-methoxy-2-methyl-3-indoleacetic acid

C₂₁H₂₂INO₃

5-Methoxy-2-methylindole-3-acetic acid

1-bromomethyl-4-iodobenzene