Technology Process of 10-Oxo-4a-((E)-3-phenyl-propenyl)-3,4,4a,9,9a,10-hexahydro-anthracene-2-carboxylic acid
There total 5 articles about 10-Oxo-4a-((E)-3-phenyl-propenyl)-3,4,4a,9,9a,10-hexahydro-anthracene-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
aluminium trichloride;
In
1,2-dichloro-ethane;
for 17h;
Ambient temperature;
DOI:10.1021/jo00251a009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / 1,4-diazabicyclo<2.2.2>octane (DABCO), glacial acetic acid / Ambient temperature
2: 1,4-diazabicyclo<2.2.2>octane (DABCO), p-(dimethylamino)pyridine (DMAP), methanesulfonyl chloride (MsCl) / CH2Cl2 / 24 h / Ambient temperature
3: 85 percent / KOH / methanol / 4.5 h / Heating
4: SOCl2 / 0.5 h / 80 °C
5: AlCl3 / 1,2-dichloro-ethane / 17 h / Ambient temperature
With
1,4-diaza-bicyclo[2.2.2]octane; dmap; potassium hydroxide; aluminium trichloride; thionyl chloride; acetic acid; methanesulfonyl chloride;
In
methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo00251a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1,4-diazabicyclo<2.2.2>octane (DABCO), p-(dimethylamino)pyridine (DMAP), methanesulfonyl chloride (MsCl) / CH2Cl2 / 24 h / Ambient temperature
2: 85 percent / KOH / methanol / 4.5 h / Heating
3: SOCl2 / 0.5 h / 80 °C
4: AlCl3 / 1,2-dichloro-ethane / 17 h / Ambient temperature
With
1,4-diaza-bicyclo[2.2.2]octane; dmap; potassium hydroxide; aluminium trichloride; thionyl chloride; methanesulfonyl chloride;
In
methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo00251a009
