{[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid

Base Information

• Chemical Name: {[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid
• CAS No.: 448184-56-3
• Molecular Formula: C₂₁H₂₆N₆O₇S
• Molecular Weight: 506.539
• Mol file: 448184-56-3.mol

Synonyms:

Chemical Property of {[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid

Chemical Property:

• Density: 1.52±0.1 g/cm3(Predicted)

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

S-DesethylpiperidinoS-[2-Carboxyl-2-oxo-ethyl-(2-aminoethyl)amino]Vardenafil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: S-Desethylpiperidino S-[2-Carboxyl-2-oxo-ethyl-(2-aminoethyl)amino] Vardenafil is an impurity of Vardenafil (V098001, 2HCl); a selective phosphodiesterase type 5 (PDE5) inhibitor.

Technology Process of {[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid

There total 4 articles about {[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H30N6O7S → {[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid (448184-56-3)

Guidance literature:

With water; sodium hydroxide; In methanol; at 25 ℃; for 0.25h;

DOI:10.1080/00397911.2011.585268

Reference yield:

C19H26N6O4S (448184-52-9) → {[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid (448184-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 0.25 h / 25 - 30 °C

2: water; sodium hydroxide / methanol / 0.25 h / 25 °C

With water; triethylamine; sodium hydroxide; In methanol;

DOI:10.1080/00397911.2011.585268

Reference yield:

4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride (224789-26-8) → {[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid (448184-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 1.33 h / 2 °C

2: triethylamine / 0.25 h / 25 - 30 °C

3: water; sodium hydroxide / methanol / 0.25 h / 25 °C

With water; triethylamine; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1080/00397911.2011.585268

upstream raw materials:

C₁₉H₂₆N₆O₄S

4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one