Technology Process of C18H19F3N6O2
There total 6 articles about C18H19F3N6O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N,N-diethylaniline; trichlorophosphate / 3 h / 105 °C
2: iron; acetic acid / 3 h / 50 °C
3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C
4: acetic acid; sodium nitrite / dichloromethane; water / 1.5 h / 20 °C
5: 1,4-dioxane / 3 h / 85 °C
With
iron; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium nitrite; trichlorophosphate;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.06.079
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid; sodium nitrite / dichloromethane; water / 1.5 h / 20 °C
2: 1,4-dioxane / 3 h / 85 °C
With
acetic acid; sodium nitrite;
In
1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.06.079
- Guidance literature:
-
Multi-step reaction with 4 steps
1: iron; acetic acid / 3 h / 50 °C
2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C
3: acetic acid; sodium nitrite / dichloromethane; water / 1.5 h / 20 °C
4: 1,4-dioxane / 3 h / 85 °C
With
iron; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.06.079