2-chloro-N-[(2Z)-3-nitroso-1,3-oxazolidin-2-ylidene]ethanamine

Base Information

• Chemical Name: 2-chloro-N-[(2Z)-3-nitroso-1,3-oxazolidin-2-ylidene]ethanamine
• CAS No.: 76310-08-2
• Molecular Formula: C5H8 Cl N3 O2
• Molecular Weight: 177.5889
• Mol file: 76310-08-2.mol

Synonyms:NSC 332566

Chemical Property of 2-chloro-N-[(2Z)-3-nitroso-1,3-oxazolidin-2-ylidene]ethanamine

Chemical Property:

• Vapor Pressure: 0.118mmHg at 25°C
• Boiling Point: 219.7°C at 760 mmHg
• Flash Point: 86.7°C
• Density: 1.5g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-N-[(2Z)-3-nitroso-1,3-oxazolidin-2-ylidene]ethanamine

There total 2 articles about 2-chloro-N-[(2Z)-3-nitroso-1,3-oxazolidin-2-ylidene]ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-<(2-chloroethyl)amino>-2-oxazoline (71353-16-7) → 2-<(2'-chloroethyl)imino>-3-nitroso-2-oxazolidine (76310-08-2)

Guidance literature:

With n-Butyl nitrite; sodium methylate; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1021/jm00135a007

Reference yield:

1,3-bis(2-chloroethyl)urea (2214-72-4) → 2-<(2'-chloroethyl)imino>-3-nitroso-2-oxazolidine (76310-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / H₂O / Heating

2: 45 percent / n-butyl nitrite, sodium methoxide / diethyl ether / 12 h / Ambient temperature

With n-Butyl nitrite; sodium methylate; In diethyl ether; water;

DOI:10.1021/jm00135a007

Reference yield:

2-<(2'-chloroethyl)imino>-3-nitroso-2-oxazolidine (76310-08-2) → 2-<(2-chloroethyl)amino>-2-oxazoline hydrochloride (73771-48-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 - 4 ℃; for 0.5h;

DOI:10.1021/jm00135a007

upstream raw materials:

2-<(2-chloroethyl)amino>-2-oxazoline

1,3-bis(2-chloroethyl)urea

Downstream raw materials:

2-<(2-chloroethyl)amino>-2-oxazoline hydrochloride

Refernces