*,R^*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine

Base Information

• Chemical Name: *,R^*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine
• CAS No.: 130551-58-5
• Molecular Formula: C₁₆H₁₆Br₂F₃NO₂
• Molecular Weight: 471.112
• Mol file: 130551-58-5.mol

Synonyms:

Chemical Property of *,R^*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of *,R^*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine

There total 5 articles about *,R^*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → *,R*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine (130551-58-5)

Guidance literature:

Multi-step reaction with 5 steps

1: BH₃*SMe₂ / tetrahydrofuran / 1.) 0 deg C, 2.) reflux, 1 h

2: pyridinium chlorochromate (PCC), acetic acid, 4A molecular sieves / H₂O; CH₂Cl₂ / 2 h / Ambient temperature

3: triphenylphosphine / CH₂Cl₂ / 0 - 20 °C

4: trifluoroacetic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 0.53 g / pyridine / CH₂Cl₂ / 3 h

With pyridine; dimethylsulfide borane complex; 4 A molecular sieve; acetic acid; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jm00174a015

Reference yield:

N-(tert-butoxycarbonyl)-L-prolinol (69610-40-8) → *,R*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine (130551-58-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridinium chlorochromate (PCC), acetic acid, 4A molecular sieves / H₂O; CH₂Cl₂ / 2 h / Ambient temperature

2: triphenylphosphine / CH₂Cl₂ / 0 - 20 °C

3: trifluoroacetic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 0.53 g / pyridine / CH₂Cl₂ / 3 h

With pyridine; 4 A molecular sieve; acetic acid; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; In dichloromethane; water;

DOI:10.1021/jm00174a015

Reference yield:

Boc-L-Pro-H (69610-41-9,117625-90-8) → *,R*)>-2-(2,2-dibromoethenyl)-1-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)pyrrolidine (130551-58-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine / CH₂Cl₂ / 0 - 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 0.53 g / pyridine / CH₂Cl₂ / 3 h

With pyridine; triphenylphosphine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00174a015

upstream raw materials:

(R)-methoxytrifluoromethylphenylacetyl chloride

(S)-2-(2,2-dibromoethenyl)-1-pyrrolidine

1-(tert-butoxycarbonyl)-L-proline

N-(tert-butoxycarbonyl)-L-prolinol