2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide

Base Information

• Chemical Name: 2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide
• CAS No.: 1257881-63-2
• Molecular Formula: C₂₈H₂₇ClN₄O₃
• Molecular Weight: 503
• Mol file: 1257881-63-2.mol

Synonyms:

Chemical Property of 2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide

There total 5 articles about 2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl N-(1,2-benzoxazol-3-yl)carbamate (1093211-84-7) + 2-(3-(4-chlorophenoxy)benzyl)-2,7-diazaspiro[3.5]nonane → 2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide (1257881-63-2)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 55 ℃;

DOI:10.1016/j.bmcl.2013.12.113

Reference yield:

3-(4-chlorophenoxy)benzaldehyde (69770-20-3) → 2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide (1257881-63-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

3: triethylamine / dimethyl sulfoxide / 55 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2013.12.113

Reference yield:

2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester (896464-16-7) → 2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid benzo[d]isoxazol-3-ylamide (1257881-63-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

3: triethylamine / dimethyl sulfoxide / 55 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2013.12.113

upstream raw materials:

phenyl N-(1,2-benzoxazol-3-yl)carbamate

3-(4-chlorophenoxy)benzaldehyde

2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester