6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one

Base Information

• Chemical Name: 6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one
• CAS No.: 1400766-73-5
• Molecular Formula: C₁₈H₁₀ClF₃O₄
• Molecular Weight: 382.723
• Mol file: 1400766-73-5.mol

Synonyms:

Chemical Property of 6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one

There total 3 articles about 6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

peucedanin (133-26-6) → 6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one (1400766-73-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform

2: sodium hydroxide; sulfuric acid / methanol

3: pyridine / 0.5 h / 0 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; tetrabutylammomium bromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; 4: |Suzuki Coupling;

DOI:10.1134/S1070428012080106

Reference yield:

peucedanine → 6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one (1400766-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; sulfuric acid / methanol

2: pyridine / 0.5 h / 0 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; tetrabutylammomium bromide; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; 3: |Suzuki Coupling;

DOI:10.1134/S1070428012080106

Reference yield:

7-hydroxy-6-(methoxycarbonyl)coumarin (52591-14-7) → 6-(methoxycarbonyl)-7-[2-chloro-5-(trifluoromethyl)phenyl]-2H-chromen-2-one (1400766-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.5 h / 0 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate; In 1,4-dioxane; 2: |Suzuki Coupling;

DOI:10.1134/S1070428012080106

upstream raw materials:

peucedanin

7-hydroxy-6-(methoxycarbonyl)coumarin