ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate

Base Information

Chemical Name:ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate
CAS No.:618385-70-9
Molecular Formula:C₂₉H₃₃FN₂O₅
Molecular Weight:508.59
Hs Code.:

ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate

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Chemical Property of ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate

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Technology Process of ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate

There total 3 articles about ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 618386-43-9
C₃₄H₄₁FN₂O₇

: 618385-70-9
ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ml400452v

Reference yield:

: vorapaxar

: 618385-70-9
ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / acetonitrile / 6 h / 60 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

2.2: 1 h

3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With dmap; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ml400452v

Reference yield:

: 618386-42-8
C₃₄H₄₁FN₂O₆

: 618385-70-9
ethyl ((1R,3aS,4aS,6R,8aR,9S,9aR)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3a-hydroxy-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 1 h

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml400452v