<2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Base Information

Chemical Name:<2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide
CAS No.:135901-94-9
Molecular Formula:C₃₈H₅₉N₇O₁₁
Molecular Weight:789.927
Hs Code.:

<2(S)-<<<N-methyl-N-<2-<N-(morpholinocarbonyl)-N-methylamino>ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide

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Chemical Property of <2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide

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Technology Process of <2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide

There total 10 articles about <2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 138606-72-1
C₅₀H₆₉N₉O₁₅

: 135901-94-9,138664-63-8
<2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm00081a019

Reference yield:

: 7757-38-2,14131-84-1,23262-78-4,27108-13-0,33823-04-0,34685-42-2,57819-52-0,78039-08-4,78039-12-0,78964-16-6,94842-76-9,149342-31-4
2,3,5,6-di-O-isopropylidene-D-mannofuranose

: 135901-94-9,138664-63-8
<2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Guidance literature:: Multi-step reaction with 5 steps

1: 4-toluenesulfonic acid / 24 h / Heating

2: 1.) Li / 1.) Et₂O, -10 deg C, 6 h, 2.) Et₂O, RT, 1 h

3: 85 percent / ammonium formate / 10percent Pd/C / methanol / 20 h / Ambient temperature

4: 1.) pivaloyl chloride, N-ethylpiperidine, Et₃N / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 20 h

5: 51 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

With 1-ethyl-piperidine; ammonium formate; pivaloyl chloride; lithium; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00081a019

Reference yield:

: 135902-09-9,138664-64-9
(2S,3R,4R,5R,6R)-2-(benzhydrylamino)-1-cyclohexyl-3,4,5,6,7-pentahydroxyheptane 4,3:7,6-diacetonide

: 135901-94-9,138664-63-8
<2(S)-<<ethyl>amino>carbonyl>oxy>-3-phenylpropionyl>histidyl <(2S,3R,4R,5R,6R)-1-cycloxexyl-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / ammonium formate / 10percent Pd/C / methanol / 20 h / Ambient temperature

2: 1.) pivaloyl chloride, N-ethylpiperidine, Et₃N / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 20 h

3: 51 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

With 1-ethyl-piperidine; ammonium formate; pivaloyl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00081a019