1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide

Base Information

• Chemical Name: 1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide
• CAS No.: 98678-47-8
• Molecular Formula: C₁₄H₁₂O₃S
• Molecular Weight: 260.313
• Mol file: 98678-47-8.mol

Synonyms:

Chemical Property of 1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide

There total 1 articles about 1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-benzylbenzaldehyde (32832-95-4) → 1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide (92912-34-0,92912-38-4,95539-05-2,98678-31-0,98678-47-8)

Guidance literature:

With sulfur dioxide; In benzene; for 20h; Irradiation; water-cooling;

DOI:10.1139/v90-309

Reference yield: 5.6%

bis((S)-methyl L-lactate) fumarate (122518-87-0) + 1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide (92912-34-0,92912-38-4,95539-05-2,98678-31-0,98678-47-8) → (S)-Methyl lactate (-)-1-hydroxy-4-phenyl-1,2,3,4-tetrahydronaphthalene-2,3-dicarboxylate (130975-96-1) + 1-Hydroxy-4-phenyl-1,2,3,4-tetrahydro-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester (130975-96-1,131064-05-6)

Guidance literature:

With zinc(II) oxide; In dichloromethane; toluene; for 0.333333h; Heating;

DOI:10.1139/v90-309

Reference yield:

1-Hydroxy-3-phenyl-1,3-dihydrobenzothiophene 2,2-dioxide (92912-34-0,92912-38-4,95539-05-2,98678-31-0,98678-47-8) → (3aR,4R,9R,9aS)-9-Hydroxy-4-phenyl-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one (131064-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / ZnO / CH₂Cl₂; toluene / 0.33 h / Heating

2: 51 percent / n-BuLi / hexane; tetrahydrofuran / 1) 15 min, -78 deg C 2) 0.5 h, r.t.

3: 71 percent / LiBHEt₃ / tetrahydrofuran / 1) 10 min, 0 deg C 2) 5 h, r.t.

With n-butyllithium; lithium triethylborohydride; zinc(II) oxide; In tetrahydrofuran; hexane; dichloromethane; toluene;

DOI:10.1139/v90-309

upstream raw materials:

2-benzylbenzaldehyde

Downstream raw materials:

(S)-Methyl lactate (-)-1-hydroxy-4-phenyl-1,2,3,4-tetrahydronaphthalene-2,3-dicarboxylate

1-Hydroxy-4-phenyl-1,2,3,4-tetrahydro-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

(3aR,4R,9R,9aS)-9-Hydroxy-4-phenyl-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one

(1R,8R,9R,12S)-10-Oxo-8-phenyl-11-oxa-tricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene-12-carboxylic acid (S)-1-methoxycarbonyl-ethyl ester