4-(5-(2-(2-(2-⁽¹⁸⁾F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Base Information

• Chemical Name: 4-(5-(2-(2-(2-⁽¹⁸⁾F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine
• CAS No.: 1287783-17-8
• Molecular Formula: C₂₁H₂₄FNO₄
• Molecular Weight: 372.426

Synonyms:

Chemical Property of 4-(5-(2-(2-(2-⁽¹⁸⁾F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-(2-(2-(2-⁽¹⁸⁾F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

There total 12 articles about 4-(5-(2-(2-(2-⁽¹⁸⁾F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H32(18)FNO6 → 4-(5-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine (1287783-17-8)

Guidance literature:

With hydrogenchloride; In water; at 120 ℃; for 0.0833333h;

DOI:10.1021/jm200057u

Reference yield:

2-(4-methylamino-phenyl)-benzofuran-5-ol → 4-(5-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine (1287783-17-8)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2: 1H-imidazole / dichloromethane / 4 h / 20 °C

3: tetrahydrofuran / Reflux

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: triethylamine / dichloromethane / 2 h / 20 °C

6: potassium carbonate; [2.2.2]cryptande / acetonitrile / 0.08 h / 120 °C

7: hydrogenchloride / water / 0.08 h / 120 °C

With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; [2.2.2]cryptande; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm200057u

Reference yield:

2-(4'-aminophenyl)-5-methoxybenzo[b]furan (888703-98-8) → 4-(5-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine (1287783-17-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium methylate / methanol / 1 h / Reflux

1.2: 2 h / Reflux

2.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

2.2: Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

4.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

5.1: tetrahydrofuran / Reflux

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

8.1: potassium carbonate; [2.2.2]cryptande / acetonitrile / 0.08 h / 120 °C

9.1: hydrogenchloride / water / 0.08 h / 120 °C

With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; sodium methylate; boron tribromide; potassium carbonate; triethylamine; [2.2.2]cryptande; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm200057u

upstream raw materials:

2-(4'-nitrophenyl)-5-methoxybenzo[b]furan

2-(4'-aminophenyl)-5-methoxybenzo[b]furan

[4-(5-methoxy-benzofuran-2-yl)-phenyl]-methyl-amine

2-hydroxy-5-methoxybenzaldehyde

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