6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate

Base Information

• Chemical Name: 6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate
• CAS No.: 124568-57-6
• Molecular Formula: C₂₁H₂₃NO₄*H₃O₄P
• Molecular Weight: 451.413
• Mol file: 124568-57-6.mol

Synonyms:

Chemical Property of 6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate

There total 3 articles about 6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-<2-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-oxoethyl>benzeneacetic acid methyl ester (124568-53-2) → 6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate (124568-57-6)

Guidance literature:

With trichlorophosphate; In toluene; for 0.5h; Heating;

DOI:10.1002/jhet.5570290103

Reference yield:

(2-Chlorocarbonylmethyl-phenyl)-acetic acid methyl ester (72686-10-3) → 6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate (124568-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: 50 percent / POCl₃ / toluene / 0.5 h / Heating

With triethylamine; trichlorophosphate; In dichloromethane; toluene;

DOI:10.1002/jhet.5570290103

Reference yield:

<2-(Methoxycarbonylmethyl)phenyl>essigsaeure (72686-08-9) → 6-<(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester phosphate (124568-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / diethyl ether / Ambient temperature

2: Et₃N / CH₂Cl₂ / 2 h

3: 50 percent / POCl₃ / toluene / 0.5 h / Heating

With thionyl chloride; triethylamine; trichlorophosphate; In diethyl ether; dichloromethane; toluene;

DOI:10.1002/jhet.5570290103

upstream raw materials:

2-<2-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-oxoethyl>benzeneacetic acid methyl ester

(2-Chlorocarbonylmethyl-phenyl)-acetic acid methyl ester

<2-(Methoxycarbonylmethyl)phenyl>essigsaeure

Downstream raw materials:

2-<(1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl)methyl>benzeneacetic acid methyl ester