7α-formyloxy-3-oxo-4-cholenic acid

Base Information

• Chemical Name: 7α-formyloxy-3-oxo-4-cholenic acid
• CAS No.: 106351-14-8
• Molecular Formula: C₂₅H₃₆O₅
• Molecular Weight: 416.558
• Mol file: 106351-14-8.mol

Synonyms:

Chemical Property of 7α-formyloxy-3-oxo-4-cholenic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7α-formyloxy-3-oxo-4-cholenic acid

There total 1 articles about 7α-formyloxy-3-oxo-4-cholenic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

4β-bromo-7α-formyloxy-3-oxo-5β-cholanic acid (106351-13-7) → 3-Oxochola-4,6-dien-24-oic acid (88179-71-9) + 7α-formyloxy-3-oxo-4-cholenic acid (106351-14-8)

Guidance literature:

With sodium acetate; 2-oxo-propionic acid; hydrazine carboxamide; Yield given. Multistep reaction; 1.) water, AcOH, 60 deg C, 30 min, then room temp., 1 h ; 2.) water, AcOH, room temp., overnight;

Reference yield: 94.0%

7α-formyloxy-3-oxo-4-cholenic acid (106351-14-8) → 7α-hydroxy-3-oxochol-4-en-24-oic acid (14772-95-3)

Guidance literature:

Reference yield:

7α-formyloxy-3-oxo-4-cholenic acid (106351-14-8) → methyl 7α-mesyloxy-3β-tosyloxy-5α-cholanate (106351-16-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent

2: 1.) Li-NH₃

3: pyridine

4: 740 mg / pyridine / Ambient temperature; overnight

With ammonia; lithium; In pyridine;

upstream raw materials:

4β-bromo-7α-formyloxy-3-oxo-5β-cholanic acid

Downstream raw materials:

7α-hydroxy-3-oxochol-4-en-24-oic acid

3α,7α-dihydroxy-5α-cholanoic acid methyl ester

methyl 7α-mesyloxy-3β-tosyloxy-5α-cholanate

methyl 3β,7α-dihydroxy-5α-cholan-24-oate