4-morpholin-4-yl-N-phenyl-6-piperazin-1-yl-1,3,5-triazin-2-amine

Base Information

• Chemical Name: 4-morpholin-4-yl-N-phenyl-6-piperazin-1-yl-1,3,5-triazin-2-amine
• CAS No.: 21665-50-9
• Molecular Formula: C₁₇H₂₃N₇O
• Molecular Weight: 341.416
• DSSTox Substance ID: DTXSID401166588
• ChEMBL ID: CHEMBL1462955
• Mol file: 21665-50-9.mol

Synonyms:4-morpholin-4-yl-N-phenyl-6-piperazin-1-yl-1,3,5-triazin-2-amine;MLS000121030;CHEMBL1462955;SCHEMBL15613217;DTXSID401166588;HMS2337B19;STL428565;(4-Morpholin-4-yl-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-phenyl-amine;AKOS000287712;SMR000118506;AN-648/25106012;4-(4-Morpholinyl)-N-phenyl-6-(1-piperazinyl)-1,3,5-triazin-2-amine;4-(morpholin-4-yl)-N-phenyl-6-(piperazin-1-yl)-1,3,5-triazin-2-amine;N-[4-(4-morpholinyl)-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-N-phenylamine;21665-50-9

Chemical Property of 4-morpholin-4-yl-N-phenyl-6-piperazin-1-yl-1,3,5-triazin-2-amine

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 341.19640838
• Heavy Atom Count: 25
• Complexity: 395

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1)C2=NC(=NC(=N2)NC3=CC=CC=C3)N4CCOCC4

Technology Process of 4-morpholin-4-yl-N-phenyl-6-piperazin-1-yl-1,3,5-triazin-2-amine

There total 2 articles about 4-morpholin-4-yl-N-phenyl-6-piperazin-1-yl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + 4-chloro-6-morpholino-N-phenyl-1,3,5-triazin-2-amine (21665-49-6) → (4-morpholin-4-yl-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-phenyl-amine (21665-50-9)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2008.10.049

Reference yield:

→ (4-morpholin-4-yl-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-phenyl-amine (21665-50-9)

Guidance literature:

aus 2-Anilino)-4-morpholino-6-chlor-s-triazin, Piperazin;

Reference yield:

methanesulfonic acid 2-(7-chloro-quinolin-4-ylamino)ethyl ester (852402-04-1) + (4-morpholin-4-yl-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-phenyl-amine (21665-50-9) → C28H32ClN9O (1099811-45-6)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; for 0.00833333h; Microwave irradiation;

DOI:10.1016/j.bmcl.2008.10.049

upstream raw materials:

piperazine

4-chloro-6-morpholino-N-phenyl-1,3,5-triazin-2-amine

Downstream raw materials:

C₂₈H₃₂ClN₉O