Technology Process of Tyr-D-Met(O)-Gly-Phe-NH-NH2
There total 11 articles about Tyr-D-Met(O)-Gly-Phe-NH-NH2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogen / Pd-black / methanol
2: acetonitrile / Ambient temperature
3: 30percent agueous H2O2 / aq. HCl / 10 h / Ambient temperature
4: TFA / 20 h / Ambient temperature
5: TEA / acetonitrile
6: 85 percent / NH2NH2*H2O / ethanol; dimethylformamide / 48 h / Ambient temperature
7: 140 mg / methanesulfonic acid / various solvent(s) / 0.5 h / Ambient temperature
With
methanesulfonic acid; TEA; hydrogen; dihydrogen peroxide; hydrazine hydrate; trifluoroacetic acid;
palladium;
In
hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.29.3646
- Guidance literature:
-
Multi-step reaction with 8 steps
1: TEA / acetonitrile / Ambient temperature
2: hydrogen / Pd-black / methanol
3: acetonitrile / Ambient temperature
4: 30percent agueous H2O2 / aq. HCl / 10 h / Ambient temperature
5: TFA / 20 h / Ambient temperature
6: TEA / acetonitrile
7: 85 percent / NH2NH2*H2O / ethanol; dimethylformamide / 48 h / Ambient temperature
8: 140 mg / methanesulfonic acid / various solvent(s) / 0.5 h / Ambient temperature
With
methanesulfonic acid; TEA; hydrogen; dihydrogen peroxide; hydrazine hydrate; trifluoroacetic acid;
palladium;
In
hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.29.3646
- Guidance literature:
-
With
methanesulfonic acid;
In
various solvent(s);
for 0.5h;
Ambient temperature;
DOI:10.1248/cpb.29.3646
