N-Phenethyl-3-phenyl-acrylamide

Base Information

• Chemical Name: N-Phenethyl-3-phenyl-acrylamide
• CAS No.: 103188-43-8
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.328
• Hs Code.: 2924299090
• UNII: U2RPT6UA5K
• Nikkaji Number: J466.381K,J103.493F
• Pharos Ligand ID: PHU3S8KLFXWH
• Metabolomics Workbench ID: 123284
• ChEMBL ID: CHEMBL1305393
• Mol file: 103188-43-8.mol

Synonyms:N-Phenethylcinnamamide;(E)-N-Phenethylcinnamamide;103188-43-8;2-Propenamide, 3-phenyl-N-(2-phenylethyl)-;(E)-N-Phenethylcinnamide;U2RPT6UA5K;55030-23-4;N-Phenethyl-3-phenyl-acrylamide;2-Propenamide, 3-phenyl-N-(2-phenylethyl)-, (2E)-;Cinnamoyl-beta-phenethylamine;3-Phenyl-N-(2-phenylethyl)-2-propenamide;MLS000863653;(2E)-3-phenyl-N-(2-phenylethyl)prop-2-enamide;SMR000440721;(E)-3-phenyl-N-(2-phenylethyl)prop-2-enamide;3-phenyl-N-(2-phenylethyl)acrylamide;UNII-U2RPT6UA5K;cid_795855;MEGxp0_002058;CHEMBL1305393;SCHEMBL16473431;BDBM58170;BOSUEWCVNFFBGV-VAWYXSNFSA-N;HMS2271G10;STK407997;(E)-N-phenethyl-3-phenyl-acrylamide;AKOS002987632;CINNAMOYL-.BETA.-PHENETHYLAMINE;F92764;(E)-3-phenyl-N-(2-phenylethyl)-2-propenamide;AB00081214-01;(2E)-3-Phenyl-N-(2-phenylethyl)-2-propenamide;SR-01000205384;(2E)-3-Phenyl-N-(2-phenylethyl)-2-propenamide #;SR-01000205384-1

Chemical Property of N-Phenethyl-3-phenyl-acrylamide

Chemical Property:

• PSA: 32.59000
• LogP: 3.89900
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 251.131014166
• Heavy Atom Count: 19
• Complexity: 286

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCNC(=O)C=CC2=CC=CC=C2
• Isomeric SMILES: C1=CC=C(C=C1)CCNC(=O)/C=C/C2=CC=CC=C2

Technology Process of N-Phenethyl-3-phenyl-acrylamide

There total 26 articles about N-Phenethyl-3-phenyl-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-phenethylcinnamimidoyl cyanide (1421426-92-7) → N-cinnamoyl-(2-phenylethyl)amine (103188-43-8,55030-23-4)

Guidance literature:

With aluminum oxide; In toluene; at 130 ℃; for 1h; Microwave irradiation; Inert atmosphere;

DOI:10.1002/chem.201202291

Reference yield: 98.0%

(E)-3-phenylacrylic acid (140-10-3) + phenethylamine (64-04-0) → (E)-3-phenyl-N-(2-phenylethyl)-2-propenamide (55030-23-4,103188-43-8)

Guidance literature:

(E)-3-phenylacrylic acid; With tris(2,2,2-trifluoroethyl) borate; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere; Sealed tube; Green chemistry;

phenethylamine; In acetonitrile; at 100 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1016/j.ejps.2018.10.028

Reference yield: 97.0%

phenethylamine (64-04-0) + Cinnamic acid (621-82-9) → N-cinnamoyl-(2-phenylethyl)amine (103188-43-8,55030-23-4)

Guidance literature:

With 4-methyl-morpholine; triazine-type dehydrocondensing polymer; In dichloromethane; at 20 ℃; for 19h;

DOI:10.1039/b501917f

upstream raw materials:

phenethylamine

Cinnamic acid

2-bromo-3-phenyl-propionic acid phenethylamide

ammonia

Downstream raw materials:

N-phenethyl-3,3-diphenyl-propionamide