threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Base Information

Chemical Name:threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one
CAS No.:121060-73-9
Molecular Formula:C₂₄H₃₁N₃O₄
Molecular Weight:425.528
Hs Code.:

threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro<piperidine-4,4'(3'H)-quinazolin>-2'(1'H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Chemical Property:

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Technology Process of threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

There total 5 articles about threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.2%

: 121061-08-3
1-<2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl>-3'-methyl-spiro-2'(1'H)-one

: 121060-73-9
threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: With L-Selectride; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield:

: 121061-01-6
1-benzyl-6'-chloro-5,6-dihydro-3-iodo-3'-methyl-spiro-2'(1'H)-one

: 121060-73-9
threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98.8 percent / H₂, triethylamine / 10percent Pd-C / H₂O; methanol / 16 h / 40 °C

2: 38.3 percent / triethylamine (TEA), NaI / ethanol / 34 h / Ambient temperature

3: 48.2 percent / 1M L-Selectride / tetrahydrofuran / 1 h / Ambient temperature

With hydrogen; L-Selectride; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 107191-02-6
1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine

: 121060-73-9
threo-1-<2-hydroxy-1-methyl-2-(3,4-dimethoxyphenyl)ethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 83.4 percent / I₂, NaI, 10percent aq. NaHCO₃ / H₂O; CH₂Cl₂ / 2 h / Ambient temperature

2: 98.8 percent / H₂, triethylamine / 10percent Pd-C / H₂O; methanol / 16 h / 40 °C

3: 38.3 percent / triethylamine (TEA), NaI / ethanol / 34 h / Ambient temperature

4: 48.2 percent / 1M L-Selectride / tetrahydrofuran / 1 h / Ambient temperature

With hydrogen; iodine; L-Selectride; sodium hydrogencarbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;