p-bromoanilide of exo-tricyclo<4.2.0.0^1,4>octane-3-carboxylic acid

Base Information

• Chemical Name: p-bromoanilide of exo-tricyclo<4.2.0.0^1,4>octane-3-carboxylic acid
• CAS No.: 75889-04-2
• Molecular Formula: C₁₅H₁₆BrNO
• Molecular Weight: 306.202
• Mol file: 75889-04-2.mol

Synonyms:

Chemical Property of p-bromoanilide of exo-tricyclo<4.2.0.0^1,4>octane-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-bromoanilide of exo-tricyclo<4.2.0.0^1,4>octane-3-carboxylic acid

There total 7 articles about p-bromoanilide of exo-tricyclo<4.2.0.0^1,4>octane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl tricyclo<4.2.0.01,4>octane-3-carboxylate (75888-97-0,75918-58-0) → p-bromoanilide of endo-tricyclo<4.2.0.01,4>octane-3-carboxylic acid (75889-04-2,75918-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. potassium hydroxide / 65 °C

2: thionyl chloride / 0.5 h / 75 °C

3: benzene / 0.03 h / 75 °C

With potassium hydroxide; thionyl chloride; In benzene;

DOI:10.1021/ja00545a012

Reference yield:

tricyclo<4.2.0.01,4>octane-3-carboxylic acid (75888-99-2,75918-53-5) → p-bromoanilide of endo-tricyclo<4.2.0.01,4>octane-3-carboxylic acid (75889-04-2,75918-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0.5 h / 75 °C

2: benzene / 0.03 h / 75 °C

With thionyl chloride; In benzene;

DOI:10.1021/ja00545a012

Reference yield:

tricyclo<4.2.0.01,4>octane-3-carboxylic acid (75888-99-2,75918-53-5) → p-bromoanilide of exo-tricyclo<4.2.0.01,4>octane-3-carboxylic acid (75889-04-2,75918-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0.5 h / 75 °C

2: benzene / 0.03 h / 75 °C

With thionyl chloride; In benzene;

DOI:10.1021/ja00545a012

upstream raw materials:

4-bromo-aniline

tricyclo<4.2.0.0^1,4>octane-3-carboxylic acid

endo-tricyclo<4.2.0.0^1,4>octane-3-carboxylic acid

methyl tricyclo<4.2.0.0^1,4>octane-3-carboxylate