L-Glutamic acid, N-[26-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]phenyl]-1,6,11, 16,21,26-hexaoxo-5,10,15,20,25-pentaazahexacos-1-yl]-, bis(1,1-dimethylethyl) ester

Base Information

Chemical Name:L-Glutamic acid, N-[26-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]phenyl]-1,6,11, 16,21,26-hexaoxo-5,10,15,20,25-pentaazahexacos-1-yl]-, bis(1,1-dimethylethyl) ester
CAS No.:103321-47-7
Molecular Formula:C48H73N13O10
Molecular Weight:992.189
Hs Code.:

L-Glutamic acid,
N-[26-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]phenyl]-1,6,11,
16,21,26-hexaoxo-5,10,15,20,25-pentaazahexacos-1-yl]-,
bis(1,1-dimethylethyl) ester

Synonyms:

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Chemical Property of L-Glutamic acid, N-[26-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]phenyl]-1,6,11, 16,21,26-hexaoxo-5,10,15,20,25-pentaazahexacos-1-yl]-, bis(1,1-dimethylethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[26-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]phenyl]-1,6,11, 16,21,26-hexaoxo-5,10,15,20,25-pentaazahexacos-1-yl]-, bis(1,1-dimethylethyl) ester

There total 10 articles about L-Glutamic acid, N-[26-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]phenyl]-1,6,11, 16,21,26-hexaoxo-5,10,15,20,25-pentaazahexacos-1-yl]-, bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 103321-47-7
(S)-2-[4-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: diphenylphosphoryl azide, Et₃N / dimethylformamide / Ambient temperature

2: 100 percent / HCl (gas), H₂ / 5percent Pd/C / methanol / 1 h

3: 47 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

4: 100 percent / HCl (gas), H₂ / 5percent Pd/C / methanol / 1 h

5: 1.) diethyl phosphorocyanidate (DEPC), Et₃N, 2.) Et₃N / 1.) DMF, 2.) DMF, 3 days

With hydrogenchloride; diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014

Reference yield:

: 1489-76-5
4-(4-Benzyloxycarbonylamino-butyrylamino)-butyric acid

: 103321-47-7
(S)-2-[4-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / dimethylformamide / 0.33 h

2: Et₃N / dimethylformamide / 0.5 h

3: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

4: 47 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

5: 100 percent / HCl (gas), H₂ / 5percent Pd/C / methanol / 1 h

6: 1.) diethyl phosphorocyanidate (DEPC), Et₃N, 2.) Et₃N / 1.) DMF, 2.) DMF, 3 days

With hydrogenchloride; barium dihydroxide; diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014

Reference yield:

: 90139-76-7
4-(4-Benzyloxycarbonylamino-butyrylamino)-butyric acid methyl ester

: 103321-47-7
(S)-2-[4-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

2: Et₃N / dimethylformamide / 0.33 h

3: Et₃N / dimethylformamide / 0.5 h

4: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

5: 47 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

6: 100 percent / HCl (gas), H₂ / 5percent Pd/C / methanol / 1 h

7: 1.) diethyl phosphorocyanidate (DEPC), Et₃N, 2.) Et₃N / 1.) DMF, 2.) DMF, 3 days

With hydrogenchloride; barium dihydroxide; diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014