2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide

Base Information

• Chemical Name: 2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide
• CAS No.: 60297-54-3
• Molecular Formula: C₁₃H₁₆N₂O₃S
• Molecular Weight: 280.348
• Mol file: 60297-54-3.mol

Synonyms:

Chemical Property of 2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide

There total 1 articles about 2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Methylhydroxylamine (593-77-1) + 2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carbonyl chloride → 2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide (60297-54-3)

Guidance literature:

In dichloromethane;

DOI:10.1016/S0040-4039(00)78000-2

Reference yield:

2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide (60297-54-3) → 3-(4-methoxy-phenyl)-1,6-dimethyl-4,4-dioxo-(1rH,5cH)-4λ6-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one (60297-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: MCPBA / CH₂Cl₂

3: KOtBu / tetrahydrofuran / -78 °C

With potassium tert-butylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)78000-2

Reference yield:

2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid hydroxy-methyl-amide (60297-54-3) → 2-(4-methoxy-phenyl)-4-methyl-1,1-dioxo-4,5-dihydro-1H-1λ6-thiazole-4-carboxylic acid methyl-(4-nitro-benzenesulfonyloxy)-amide (60297-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: MCPBA / CH₂Cl₂

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)78000-2

upstream raw materials:

N-Methylhydroxylamine

Downstream raw materials:

2-(4-methoxy-phenyl)-4-methyl-4,5-dihydro-thiazole-4-carboxylic acid methyl-(4-nitro-benzenesulfonyloxy)-amide

3-(4-methoxy-phenyl)-1,6-dimethyl-4,4-dioxo-(1rH,5cH)-4λ⁶-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one

2-(4-methoxy-phenyl)-4-methyl-1,1-dioxo-4,5-dihydro-1H-1λ⁶-thiazole-4-carboxylic acid methyl-(4-nitro-benzenesulfonyloxy)-amide