Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Base Information

• Chemical Name: Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester
• CAS No.: 70900-89-9
• Molecular Formula: C₄₁H₃₇N₂O₆PS₂
• Molecular Weight: 748.86

Synonyms:

Chemical Property of Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Chemical Property:

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Technology Process of Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

There total 2 articles about Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) + 5'-O-tritylthymidine (7791-71-1) → Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (70900-89-9)

Guidance literature:

With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; Yield given. Multistep reaction; 1.) RT, 30 min, 2.) RT, 20 min;

DOI:10.1246/bcsj.54.3815

Reference yield:

→ O5'-trityl-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester (70900-89-9)

Guidance literature:

Thymidinderivat 3,Phosphordithioat 1a;

DOI:10.1021/jo01327a077

Reference yield: 97.0%

Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (70900-89-9) → C29H28N2O8P(1-)

Guidance literature:

With pyridine; water; silver(I) acetate; for 18h; Ambient temperature;

DOI:10.1246/bcsj.54.3815

upstream raw materials:

cyclohexylammonium S,S-diphenyl phosphorodithioate

5'-O-tritylthymidine

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