(2Z)-4-(4-Chlorophenyl)-2-hydroxy-4-oxo-2-butenoic acid

Base Information

Chemical Name:(2Z)-4-(4-Chlorophenyl)-2-hydroxy-4-oxo-2-butenoic acid
CAS No.:103344-71-4
Molecular Formula:C10H7ClO4
Molecular Weight:226.616
Hs Code.:
DSSTox Substance ID:DTXSID801204437
Mol file:103344-71-4.mol

Synonyms:DTXSID801204437;(2Z)-4-(4-Chlorophenyl)-2-hydroxy-4-oxo-2-butenoic acid;103344-71-4

Suppliers and Price of (2Z)-4-(4-Chlorophenyl)-2-hydroxy-4-oxo-2-butenoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (2Z)-4-(4-Chlorophenyl)-2-hydroxy-4-oxo-2-butenoic acid

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:226.0032864
Heavy Atom Count:15
Complexity:290

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=CC(=O)C(=O)O)O)Cl
Isomeric SMILES:C1=CC(=CC=C1/C(=C\C(=O)C(=O)O)/O)Cl

Technology Process of (2Z)-4-(4-Chlorophenyl)-2-hydroxy-4-oxo-2-butenoic acid

There total 4 articles about (2Z)-4-(4-Chlorophenyl)-2-hydroxy-4-oxo-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 294624-23-0
(Z)-ethyl 4-(4-chlorophenyl)-2-hydroxy-4-oxo-2-butenoate

: 103344-71-4
(Z)-4-(4-chlorophenyl)-2-hydroxy-4-oxobut-2-enoic acid

Guidance literature:: (Z)-ethyl 4-(4-chlorophenyl)-2-hydroxy-4-oxo-2-butenoate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2 - 3;
DOI:10.1039/c5ra03354c

Reference yield:

: 99-91-2
para-chloroacetophenone

: 103344-71-4
(Z)-4-(4-chlorophenyl)-2-hydroxy-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / methanol / 0 - 20 °C

2: aq. HCl / 4 h / 20 °C

With hydrogenchloride; sodium methylate; In methanol;
DOI:10.1021/jm990396t