Technology Process of 2,3-Naphthalenediol,
1-chloro-5,6,7,8-tetrahydro-7-[[2-(4-hydroxyphenyl)ethyl]propylamino]-,
hydrobromide
There total 15 articles about 2,3-Naphthalenediol,
1-chloro-5,6,7,8-tetrahydro-7-[[2-(4-hydroxyphenyl)ethyl]propylamino]-,
hydrobromide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
for 24h;
Ambient temperature;
DOI:10.1021/jm00159a010
- Guidance literature:
-
Multi-step reaction with 15 steps
1: 52.8 g / NaOMe / methanol / 2 h / Heating
2: 52.1 g / H2 / 10percent Pd/C / ethyl acetate / 25 °C / 3361.5 Torr
3: 92 percent / methanesulfonic acid (MSA) / 0.25 h / 100 °C
4: 99 percent / 70percent aq. HClO4, H2 / 10percent Pd/C / acetic acid / 4 h / 25 °C / 2327.2 Torr
5: 25.26 g / aq. KOH / methanol / 24 h / Heating
6: SOCl2 / 4 h / 60 °C
7: aq. NaN3 / acetone / 0.5 h / 0 - 20 °C
8: toluene / 1 h / 100 °C
9: 6 h / 100 °C
10: 96 percent / concd. HCl, H2 / Pd/C / ethanol / 25 °C / 2585.7 Torr
11: 67 percent / Et3N / tetrahydrofuran / 16 h / 25 °C
12: 87 percent / BH3 / tetrahydrofuran / 2 h / Heating
13: 1.5 g / aq. K2CO3 / CHCl3 / 1 h / 25 °C
14: BH3 / tetrahydrofuran / 2 h / Heating
15: 50 percent / BBr3 / CH2Cl2 / 24 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; thionyl chloride; sodium azide; perchloric acid; methanesulfonic acid; borane; hydrogen; sodium methylate; boron tribromide; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; acetic acid; ethyl acetate; acetone; toluene;
DOI:10.1021/jm00159a010
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 6 h / 100 °C
2: 96 percent / concd. HCl, H2 / Pd/C / ethanol / 25 °C / 2585.7 Torr
3: 67 percent / Et3N / tetrahydrofuran / 16 h / 25 °C
4: 87 percent / BH3 / tetrahydrofuran / 2 h / Heating
5: 1.5 g / aq. K2CO3 / CHCl3 / 1 h / 25 °C
6: BH3 / tetrahydrofuran / 2 h / Heating
7: 50 percent / BBr3 / CH2Cl2 / 24 h / Ambient temperature
With
hydrogenchloride; borane; hydrogen; boron tribromide; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00159a010
