2-(Benzyloxy)-1-phenylethanone

Base Information

• Chemical Name: 2-(Benzyloxy)-1-phenylethanone
• CAS No.: 103394-86-1
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• European Community (EC) Number: 867-347-5
• Nikkaji Number: J919.683H
• Mol file: 103394-86-1.mol

Synonyms:2-(Benzyloxy)-1-phenylethan-1-one;103394-86-1;2-(benzyloxy)-1-phenylethanone;2-benzyloxy-acetophenone;SCHEMBL657234;MRSDBRAGNWAUPL-UHFFFAOYSA-N;AKOS011308021;CS-0259411;EN300-7325059;Z906195418

Chemical Property of 2-(Benzyloxy)-1-phenylethanone

Chemical Property:

• Melting Point: 62-64 °C
• Boiling Point: 353.5±25.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.106±0.06 g/cm3(Predicted)
• LogP: 3.08610
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 225

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COCC(=O)C2=CC=CC=C2

Technology Process of 2-(Benzyloxy)-1-phenylethanone

There total 20 articles about 2-(Benzyloxy)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-O-benzyl-1-phenylethane-1,2-diol (838-66-4) → 2-(benzyloxy)-1-phenylethan-1-one (103394-86-1)

Guidance literature:

2-O-benzyl-1-phenylethane-1,2-diol; With oxalyl dichloride; dimethyl sulfoxide; In diethyl ether; dichloromethane; at -78 ℃; for 0.75h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ja3032345

Reference yield: 88.0%

→ 2-(benzyloxy)-1-phenylethan-1-one (103394-86-1)

Guidance literature:

Reference yield: 87.0%

2-diazo-acetophenone (3282-32-4) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzyloxy)-1-phenylethan-1-one (103394-86-1)

Guidance literature:

With indium(III) triflate; In toluene; at 25 ℃; Inert atmosphere;

DOI:10.1021/ol802147h

upstream raw materials:

benzyloxyacetonitrile

5-Benzyloxymethyl-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-one

benzyl alcohol

O-benzyl 2,2,2-trichloroacetimidate

Downstream raw materials:

2-hydroxy-2,3-diphenylpropanoic acid

C₁₅H₁₄O₂