Technology Process of 22-hydroxy-N,N,N-trimethyl-19-(phenylmethoxy)-2,5,8,17,21,23-hexaoxa-22-phosphapentacosan-25-aminium, 22-oxide, hydroxide, inner salt
There total 10 articles about 22-hydroxy-N,N,N-trimethyl-19-(phenylmethoxy)-2,5,8,17,21,23-hexaoxa-22-phosphapentacosan-25-aminium, 22-oxide, hydroxide, inner salt which
guide to synthetic route it.
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synthetic route:
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113581-61-6
22-hydroxy-N,N,N-trimethyl-19-(phenylmethoxy)-2,5,8,17,21,23-hexaoxa-22-phosphapentacosan-25-aminium, 22-oxide, hydroxide, inner salt
- Guidance literature:
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Multi-step reaction with 10 steps
1: 80 percent / NaH / dimethylformamide / 3 h
2: 1.) borane, 2-methyl-2-butene, 2.) 3 N NaOH, aq. 30percent H2O2 / 1.) THF, 3 h, 2.) THF, 0.5 h
3: 65 percent / pyridine / 5 °C
4: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, overnight
5: pyridine / tetrahydrofuran
6: NaH / dimethylformamide
7: Amberlyst-15 ion-exchange resin / methanol / 1 h
8: triethylamine / CCl4 / 1.5 h
9: aq. 0.5 M AcONa / tetrahydrofuran / 3 h
10: acetonitrile; CHCl3 / 3 h / Heating
With
pyridine; sodium hydroxide; 2-methyl-but-2-ene; Amberlyst-15 ion-exchange resin; borane; dihydrogen peroxide; sodium acetate; sodium hydride; triethylamine;
In
tetrahydrofuran; methanol; tetrachloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00157a038
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113581-61-6
22-hydroxy-N,N,N-trimethyl-19-(phenylmethoxy)-2,5,8,17,21,23-hexaoxa-22-phosphapentacosan-25-aminium, 22-oxide, hydroxide, inner salt
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 80 percent / NaH / dimethylformamide / 3 h
2: 1.) borane, 2-methyl-2-butene, 2.) 3 N NaOH, aq. 30percent H2O2 / 1.) THF, 3 h, 2.) THF, 0.5 h
3: 65 percent / pyridine / 5 °C
4: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, overnight
5: pyridine / tetrahydrofuran
6: NaH / dimethylformamide
7: Amberlyst-15 ion-exchange resin / methanol / 1 h
8: triethylamine / CCl4 / 1.5 h
9: aq. 0.5 M AcONa / tetrahydrofuran / 3 h
10: acetonitrile; CHCl3 / 3 h / Heating
With
pyridine; sodium hydroxide; 2-methyl-but-2-ene; Amberlyst-15 ion-exchange resin; borane; dihydrogen peroxide; sodium acetate; sodium hydride; triethylamine;
In
tetrahydrofuran; methanol; tetrachloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00157a038
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-
113581-61-6
22-hydroxy-N,N,N-trimethyl-19-(phenylmethoxy)-2,5,8,17,21,23-hexaoxa-22-phosphapentacosan-25-aminium, 22-oxide, hydroxide, inner salt
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 65 percent / pyridine / 5 °C
2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, overnight
3: pyridine / tetrahydrofuran
4: NaH / dimethylformamide
5: Amberlyst-15 ion-exchange resin / methanol / 1 h
6: triethylamine / CCl4 / 1.5 h
7: aq. 0.5 M AcONa / tetrahydrofuran / 3 h
8: acetonitrile; CHCl3 / 3 h / Heating
With
pyridine; Amberlyst-15 ion-exchange resin; sodium acetate; sodium hydride; triethylamine;
In
tetrahydrofuran; methanol; tetrachloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00157a038
