[(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid

Base Information

Chemical Name:[(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid
CAS No.:1053640-17-7
Molecular Formula:C₄₃H₇₂O₈Si₂
Molecular Weight:773.211
Hs Code.:

[(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid

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Chemical Property of [(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid

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Technology Process of [(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid

There total 6 articles about [(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445-91-6
(S)-1-phenylethanol

: 1053640-17-7
[(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / KH / tetrahydrofuran / 20 h / Heating

2.1: LiHMDS / tetrahydrofuran; various solvent(s) / 0.5 h / -78 °C

3.1: CF₃COOH; DMAP; pyridine / CH₂Cl₂

3.2: ZnBr₂

With pyridine; dmap; potassium hydride; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1.1: Alkylation / 2.1: silylation / 3.1: Acylation / 3.2: Condensation;
DOI:10.1021/jo0002801

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1053640-17-7
[(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / KH / tetrahydrofuran / 20 h / Heating

2.1: LiHMDS / tetrahydrofuran; various solvent(s) / 0.5 h / -78 °C

4.1: LiHMDS / tetrahydrofuran; various solvent(s) / 0.5 h / -78 °C

5.1: CF₃COOH; DMAP; pyridine / CH₂Cl₂

5.2: ZnBr₂

With pyridine; dmap; potassium hydride; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1.1: Alkylation / 2.1: silylation / 4.1: silylation / 5.1: Acylation / 5.2: Condensation;
DOI:10.1021/jo0002801

Reference yield:

: 287400-90-2
(S)-methylbenzyloxyacetic acid

: 1053640-17-7
[(3S,4R,5R,6R)-5-(4-Methoxy-benzyloxy)-3-methyl-4-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-((S)-1-phenyl-ethoxy)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran; various solvent(s) / 0.5 h / -78 °C

2.1: CF₃COOH; DMAP; pyridine / CH₂Cl₂

2.2: ZnBr₂

With pyridine; dmap; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1.1: silylation / 2.1: Acylation / 2.2: Condensation;
DOI:10.1021/jo0002801