methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate

Base Information

Chemical Name:methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate
CAS No.:76453-66-2
Molecular Formula:C₁₀H₁₃NO₃
Molecular Weight:195.218
Hs Code.:

Synonyms:

Suppliers and Price of methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate

There total 2 articles about methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6118-51-0
exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride

: 76453-66-2,76497-38-6,82337-06-2,82337-07-3,112967-31-4
methylester of exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-endo-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / dimethylformamide / Ambient temperature

2: 95.3 percent / H₂ / 5percent Pd-C / methanol

5: 97.1 percent / K₂CO₃ / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 6118-51-0
exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride

: 76453-66-2,76497-38-6,82337-06-2,82337-07-3,112967-31-4
methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / dimethylformamide / Ambient temperature

2: 95.3 percent / H₂ / 5percent Pd-C / methanol

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 76453-66-2,76497-38-6,82337-06-2,82337-07-3,112967-31-4
methyl exo-3-(cyanomethyl)-7-oxabicyclo<2.2.1>heptane-exo-2-carboxylate

: 112916-75-3,112966-80-0,112967-12-1,112967-15-4,121423-58-3,121423-60-7,121423-66-3,121423-71-0,121423-93-6,121423-98-1
(5Z)-7-(3-endo-(benzenesulfonylamino)-7-oxabicyclo<2.2.1>heptan-2-exo-yl)hept-5-enoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 77 percent / 10percent KOH / methanol / 1 h / Ambient temperature

2: 1.) Et₃N, ClCOOEt; 2.) NaN₃ / 1.) H₂O-acetone, 0 deg C; 2.) H₂O-acetone, 3 deg C

3: benzene / Heating

4: benzene / Heating

5: 1M diisobutylaluminum hydride (DiBAL) / hexane; toluene / 6 h / -20 °C

6: 1.) tert-BuOK / 1.) THF, RT; 2.) THF, RT

7: diethyl ether

8: 67.9 percent / 1.) CF₃COOH; 2.) Et₃N / Ambient temperature; 2.) CH₂Cl₂

9: 10percent aq. NaOH / methanol / Ambient temperature

With potassium hydroxide; sodium hydroxide; sodium azide; potassium tert-butylate; chloroformic acid ethyl ester; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; In methanol; diethyl ether; hexane; toluene; benzene;
DOI:10.1248/cpb.37.327