3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

Base Information

• Chemical Name: 3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride
• CAS No.: 123724-81-2
• Molecular Formula: C₂₀H₂₃N₉O₄S*ClH
• Molecular Weight: 521.987
• Mol file: 123724-81-2.mol

Synonyms:

Chemical Property of 3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride

There total 5 articles about 3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-(formylamino)-thiazole-4-carboxylic acid (123724-92-5) + 3-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>propionamidine hydrochloride (97950-75-9) → 3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride (123724-81-2)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; N,N-dimethyl-formamide; for 12h; Ambient temperature;

DOI:10.1021/jo00289a057

Reference yield:

3-({1-Methyl-4-[(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carbonyl}-amino)-propionimidic acid ethyl ester (769910-02-3) → 3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride (123724-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia / ethanol

2: hydrogen / 10percent Pd/C / dimethylformamide; methanol / 760 Torr / Ambient temperature

3: 49 percent / HOBT, DCC / dimethylsulfoxide; dimethylformamide / 12 h / Ambient temperature

With ammonia; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jo00289a057

Reference yield:

N-(3-amino-3-iminopropyl)-1-methyl-4-{[(1-methyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrole-2-carboxamide hydrochloride (14555-80-7) → 3-<1-methyl-4-<1-methyl-4-(2-(formylamino)thiazole-4-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride (123724-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / 10percent Pd/C / dimethylformamide; methanol / 760 Torr / Ambient temperature

2: 49 percent / HOBT, DCC / dimethylsulfoxide; dimethylformamide / 12 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jo00289a057

upstream raw materials:

2-(formylamino)-thiazole-4-carboxylic acid

3-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>propionamidine hydrochloride

ethyl 2-(formylamino)-thiazole-4-carboxylate

3-({1-Methyl-4-[(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carbonyl}-amino)-propionimidic acid ethyl ester