C₁₈H₃₁NO₃S

Base Information

• Chemical Name: C₁₈H₃₁NO₃S
• CAS No.: 1285721-33-6
• Molecular Formula: C₁₈H₃₁NO₃S
• Molecular Weight: 341.515
• Mol file: 1285721-33-6.mol

Synonyms:

Chemical Property of C₁₈H₃₁NO₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₃₁NO₃S

There total 4 articles about C₁₈H₃₁NO₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BF4(1-)*C11H20NO2S(1+) + cyclohexanecarbaldehyde (2043-61-0) → C18H31NO3S (1285721-33-6) + C18H31NO3S

Guidance literature:

BF₄^(1-)*C₁₁H₂₀NO₂S⁽¹⁺⁾; With sodium hydroxide; In water; dimethyl sulfoxide; tert-butyl alcohol; at 25 ℃; for 1h; Inert atmosphere;

cyclohexanecarbaldehyde; In water; dimethyl sulfoxide; tert-butyl alcohol; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1021/jo1025964

Reference yield:

(S)-valinol (2026-48-4,473-75-6) → C18H31NO3S (1285721-33-6) + C18H31NO3S

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: acetonitrile / 12 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / water; dimethyl sulfoxide; tert-butyl alcohol / 1 h / 25 °C / Inert atmosphere

3.2: Inert atmosphere

With n-butyllithium; sodium hydroxide; In tetrahydrofuran; hexane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;

DOI:10.1021/jo1025964

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → C18H31NO3S (1285721-33-6) + C18H31NO3S

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: acetonitrile / 12 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / water; dimethyl sulfoxide; tert-butyl alcohol / 1 h / 25 °C / Inert atmosphere

4.2: Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; sodium hydroxide; In tetrahydrofuran; hexane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;

DOI:10.1021/jo1025964

upstream raw materials:

cyclohexanecarbaldehyde

(S)-valinol

L-valine