Technology Process of (+/-)-17-phenoxy-18,19,20-trinor-6,7E-epoxy-1E,8E,10E,12Z,15Z-eicosapentaene
There total 7 articles about (+/-)-17-phenoxy-18,19,20-trinor-6,7E-epoxy-1E,8E,10E,12Z,15Z-eicosapentaene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) ethylmagnesium bromide / 1.) THF, cuprous chloride, 65 deg C; 2.) room temp., 3 h
2: 95 percent / carbon tetrabromide, triphenylphosphine / CH2Cl2 / 4 h / 0 °C
3: 70 percent / acetonitrile / 4 h / Heating
4: 1.62 g / H2 / Pd/BaSO4 / ethyl acetate; pyridine
5: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 30 min.; 2.) 20 deg C, 24 h
With
carbon tetrabromide; ethylmagnesium bromide; hydrogen; triphenylphosphine; lithium diisopropyl amide;
Pd-BaSO4;
In
pyridine; dichloromethane; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) butyllithium / 1.) THF, -40 deg C, 1.5 h; 2.) 60 deg C, 3 h
2: 70 percent / PBr3, pyridine / diethyl ether / 1.) -30 deg C, 2 h; 2.) 20 deg C, 3 h; 30 deg C, 45 min
3: 1.) ethylmagnesium bromide / 1.) THF, cuprous chloride, 65 deg C; 2.) room temp., 3 h
4: 95 percent / carbon tetrabromide, triphenylphosphine / CH2Cl2 / 4 h / 0 °C
5: 70 percent / acetonitrile / 4 h / Heating
6: 1.62 g / H2 / Pd/BaSO4 / ethyl acetate; pyridine
7: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 30 min.; 2.) 20 deg C, 24 h
With
pyridine; n-butyllithium; carbon tetrabromide; ethylmagnesium bromide; hydrogen; phosphorus tribromide; triphenylphosphine; lithium diisopropyl amide;
Pd-BaSO4;
In
pyridine; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / PBr3, pyridine / diethyl ether / 1.) -30 deg C, 2 h; 2.) 20 deg C, 3 h; 30 deg C, 45 min
2: 1.) ethylmagnesium bromide / 1.) THF, cuprous chloride, 65 deg C; 2.) room temp., 3 h
3: 95 percent / carbon tetrabromide, triphenylphosphine / CH2Cl2 / 4 h / 0 °C
4: 70 percent / acetonitrile / 4 h / Heating
5: 1.62 g / H2 / Pd/BaSO4 / ethyl acetate; pyridine
6: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 30 min.; 2.) 20 deg C, 24 h
With
pyridine; carbon tetrabromide; ethylmagnesium bromide; hydrogen; phosphorus tribromide; triphenylphosphine; lithium diisopropyl amide;
Pd-BaSO4;
In
pyridine; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;
