(S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride

Base Information

• Chemical Name: (S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride
• CAS No.: 93503-09-4
• Molecular Formula: C₁₄H₂₁NO*ClH
• Molecular Weight: 255.788
• Mol file: 93503-09-4.mol

Synonyms:

Chemical Property of (S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(S)-(-)-7-Methoxy-N-propyl-2-aminotetralinehydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride

There total 1 articles about (S)-(-)-7-methoxy-N-propyl-2-aminotetraline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine (148258-42-8) → (S)-(-)-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93503-09-4)

Guidance literature:

(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine; With (+)-4-(2-chlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide; In ethanol; Heating; Resolution of racemate;

With water; sodium hydroxide; at 20 ℃; for 2h;

With hydrogenchloride;

DOI:10.1016/j.bmc.2010.06.025

Reference yield: 32.0%

2-chloro-1-(4-(4-(pyridin-4-yl)phenyl)piperazin-1-yl)ethanone (1245728-35-1) + (S)-(-)-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93503-09-4) → (-)-2-((7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)-1-(4-(4-(pyridin-4-yl)phenyl)piperazin-1-yl)ethanone

Guidance literature:

With potassium carbonate; In acetonitrile; for 1h; Reflux;

DOI:10.1016/j.bmc.2010.06.025

Reference yield:

(S)-(-)-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93503-09-4) → [125I]-(+)-7-OH-PIPAT (148258-46-2,159559-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / acetone / Heating

2: 1.) (n-Bu)3SnH, AIBN, 2.) I₂ / 1.) toluene, from 95 to 100 deg C, 4 h, 2.) CHCl₃, RT, overnight

3: BBr₃ / CH₂Cl₂ / Ambient temperature

With 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; boron tribromide; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/jm00078a021

upstream raw materials:

(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine

Downstream raw materials:

[125I]-(+)-7-OH-PIPAT

(S)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin

(S)-(-)-7-hydroxy-2-(di-n-propylamino)tetralin

Refernces