dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride

Base Information

• Chemical Name: dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride
• CAS No.: 1313432-04-0
• Molecular Formula: C₇H₇IN₂O₄*ClH
• Molecular Weight: 346.509
• Mol file: 1313432-04-0.mol

Synonyms:

Chemical Property of dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride

There total 2 articles about dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-iodo-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester (1027819-68-6) → dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride (1313432-04-0)

Guidance literature:

With hydrogenchloride; In methanol; water; for 0.25h;

DOI:10.1039/c0nj00774a

Reference yield:

3,5-dicarbomethoxypyrazole (4077-76-3) → dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride (1313432-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate; iodine / acetonitrile / Reflux

2: hydrogenchloride / methanol; water / 0.25 h

With hydrogenchloride; ammonium cerium (IV) nitrate; iodine; In methanol; water; acetonitrile;

DOI:10.1039/c0nj00774a

Reference yield:

dimethyl-4-iodo-3,5-pyrazolecarboxylate hydrochloride (1313432-04-0) → dimethyl-4-phenyl-1-(tetrahydropyran-2-yl)-3,5-pyrazolecarboxylate (1313431-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane

2: C₁₀H₁₆N₂O₈*Cl₂Pd; tetraethylammonium bromide; potassium carbonate / water / 2 h / Inert atmosphere; Reflux

With C₁₀H₁₆N₂O₈*Cl₂Pd; tetraethylammonium bromide; potassium carbonate; In dichloromethane; water; 2: Suzuki-Miyaura coupling;

DOI:10.1039/c0nj00774a

upstream raw materials:

4-iodo-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester

3,5-dicarbomethoxypyrazole

Downstream raw materials:

dimethyl-4-phenyl-1-(tetrahydropyran-2-yl)-3,5-pyrazolecarboxylate