(S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester

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Chemical Name:(S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester
CAS No.:174747-55-8
Molecular Formula:C₄₂H₆₆Cl₃N₇O₁₁
Molecular Weight:951.385
Hs Code.:

(S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester

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Chemical Property of (S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester

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Technology Process of (S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester

There total 6 articles about (S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(S)-1-[(R)-1-((S)-1-Azidocarbonyl-2-methyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

: (S)-3-Amino-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester; compound with trifluoro-acetic acid

: 174747-55-8
(S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 4 ℃; for 96h; Yield given;
DOI:10.1248/cpb.44.5

Reference yield:

: 13798-75-9
N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

: 174747-55-8
(S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75.6 percent / Et₃N / ethyl acetate / Ambient temperature

2: anisole / 1 h / 0 °C

3: Et₃N / dimethylformamide / 96 h / 4 °C

With methoxybenzene; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.5

Reference yield:

: 174747-50-3
N'-((R)-2-Amino-4-methyl-pentanoyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester

: 174747-55-8
(S)-3-{(S)-2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-N-{(R)-3-methyl-1-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-butyl}-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75.6 percent / Et₃N / ethyl acetate / Ambient temperature

2: anisole / 1 h / 0 °C

3: Et₃N / dimethylformamide / 96 h / 4 °C

With methoxybenzene; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.5