(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester

Base Information

• Chemical Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester
• CAS No.: 122876-19-1
• Molecular Formula: C₃₄H₄₇F₃O₆Si
• Molecular Weight: 636.824
• Mol file: 122876-19-1.mol

Synonyms:

Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester

There total 6 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methyl-heptanoyl chloride (70767-37-2) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester (122876-19-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) n-butyllithium, diisopropylamine / 1) hexane, THF, 10 min, -78 deg C, 2) THF, 1 h, -78 deg C

2: water / ethanol / 0.17 h / Heating

3: 18 percent / sodium borohydride / methanol / 1 h / Ambient temperature

4: 77 percent / imidazole / dimethylsulfoxide / 12 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; water; diisopropylamine; In methanol; ethanol; dimethyl sulfoxide;

Reference yield:

(S)-(-)-3-Trimethylsiloxymethyl-4-butanolide (85701-09-3) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester (122876-19-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) n-butyllithium, diisopropylamine / 1) hexane, THF, 10 min, -78 deg C, 2) THF, 1 h, -78 deg C

2: water / ethanol / 0.17 h / Heating

3: 18 percent / sodium borohydride / methanol / 1 h / Ambient temperature

4: 77 percent / imidazole / dimethylsulfoxide / 12 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; water; diisopropylamine; In methanol; ethanol; dimethyl sulfoxide;

Reference yield:

(3R)-(-)-3-Hydroxymethyl-2-(6-methylheptanoyl)-4-butanolide (51311-41-2) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-{(3S,4S)-4-[dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-2-oxo-tetrahydro-furan-3-yl}-6-methyl-heptyl ester (122876-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 18 percent / sodium borohydride / methanol / 1 h / Ambient temperature

2: 77 percent / imidazole / dimethylsulfoxide / 12 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; In methanol; dimethyl sulfoxide;

upstream raw materials:

(R)-methoxytrifluoromethylphenylacetyl chloride

(3S,4S)-4-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxymethyl]-3-((R)-1-hydroxy-6-methyl-heptyl)-dihydro-furan-2-one

6-methyl-heptanoyl chloride

(S)-(-)-3-Trimethylsiloxymethyl-4-butanolide