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Technology Process of C49H52N5O19P

C49H52N5O19P

Base Information
  • Chemical Name:C49H52N5O19P
  • CAS No.:199480-66-5
  • Molecular Formula:C49H52N5O19P
  • Molecular Weight:1045.95
  • Hs Code.:
C<sub>49</sub>H<sub>52</sub>N<sub>5</sub>O<sub>19</sub>P

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Chemical Property of C49H52N5O19P
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Technology Process of C49H52N5O19P

There total 10 articles about C49H52N5O19P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

C<sub>49</sub>H<sub>52</sub>N<sub>5</sub>O<sub>19</sub>P
199480-66-5

C49H52N5O19P

Guidance literature:
Multi-step reaction with 4 steps
1: pyridine; CH2Cl2
2: diisopropylammonium tetrazolide / CH2Cl2
3: tetrazole / acetonitrile
4: I2, 2,6-lutidine / H2O; tetrahydrofuran
With 2,6-dimethylpyridine; 1H-tetrazole; N,N-diisopropylamine tetrazolide; iodine; In tetrahydrofuran; pyridine; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)01478-6

Reference yield:

2'-deoxy-2'-α-C-(2-propenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
151384-08-6

2'-deoxy-2'-α-C-(2-propenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

C<sub>49</sub>H<sub>52</sub>N<sub>5</sub>O<sub>19</sub>P
199480-66-5

C49H52N5O19P

Guidance literature:
Multi-step reaction with 8 steps
1: 91 percent / CH2Cl2 / 16 h
2: 1.) O3, 2.) NaBH4 / 1.) CH2Cl2, -78 deg C, 5.5 min, 2.) MeOH, 0 deg C, 10 min
3: pyridine
4: NEt3*HF / tetrahydrofuran
5: pyridine; CH2Cl2
6: diisopropylammonium tetrazolide / CH2Cl2
7: tetrazole / acetonitrile
8: I2, 2,6-lutidine / H2O; tetrahydrofuran
With 2,6-dimethylpyridine; 1H-tetrazole; sodium tetrahydroborate; N,N-diisopropylamine tetrazolide; iodine; ozone; triethylamine hydrofluoride; In tetrahydrofuran; pyridine; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)01478-6

Reference yield:

2'-deoxy-2'-α-C-(acetoxymethyl)uridine
692781-24-1

2'-deoxy-2'-α-C-(acetoxymethyl)uridine

C<sub>49</sub>H<sub>52</sub>N<sub>5</sub>O<sub>19</sub>P
199480-66-5

C49H52N5O19P

Guidance literature:
Multi-step reaction with 4 steps
1: pyridine; CH2Cl2
2: diisopropylammonium tetrazolide / CH2Cl2
3: tetrazole / acetonitrile
4: I2, 2,6-lutidine / H2O; tetrahydrofuran
With 2,6-dimethylpyridine; 1H-tetrazole; N,N-diisopropylamine tetrazolide; iodine; In tetrahydrofuran; pyridine; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)01478-6
upstream raw materials:

2',3'-di-O-acetyl-uridine

Acetic acid (2R,3R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl ester

4,4'-dimethoxytrityl chloride

2'-deoxy-2'-α-C-(2-propenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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