Technology Process of (1RS),(2RS)-1-hydroxy-1-<(1E)-1-phenylthio-oct-2-enyl>-6-(4-pyrrolidin-1-ylcarbonylbutoxy)indan
There total 15 articles about (1RS),(2RS)-1-hydroxy-1-<(1E)-1-phenylthio-oct-2-enyl>-6-(4-pyrrolidin-1-ylcarbonylbutoxy)indan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 68 percent / n-butyl-lithium / tetrahydrofuran / 1.) -60 deg C, 15 min, 2.) -50 deg C, 1.5 h
2: 61 percent / phosphorus tribromide / dimethylformamide / 0.17 h / 0 °C
3: lithium di-isopropylamide / tetrahydrofuran / 1.) -75 deg C, 15 min, 2.) -70 deg C, 3 h
With
n-butyllithium; phosphorus tribromide; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 79 percent / aluminium bromide / benzene / 4.5 h / Heating
2: 74 percent / sodium methoxide / methanol / 50 h / Heating
3: sodium borohydride / methanol / 0.33 h / Ambient temperature
4: toluene-p-sulphonic acid / benzene / 1.5 h / Heating
5: 80 percent / sodium carbonate, water / dioxane / 5.5 h / Heating
6: 90 percent / triethylamine, ethyl chloroformate / CH2Cl2 / 1.17 h / Ambient temperature
7: 4.4 g / N-bromosuccinimide, water / tetrahydrofuran / 20 h / Ambient temperature
8: 2.24 g / aq.potassium hydroxide / dioxane / 0.25 h / Ambient temperature
9: lithium di-isopropylamide / tetrahydrofuran / 1.) -75 deg C, 15 min, 2.) -70 deg C, 3 h
With
potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; aluminum tri-bromide; water; sodium methylate; chloroformic acid ethyl ester; sodium carbonate; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; benzene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 74 percent / sodium methoxide / methanol / 50 h / Heating
2: sodium borohydride / methanol / 0.33 h / Ambient temperature
3: toluene-p-sulphonic acid / benzene / 1.5 h / Heating
4: 80 percent / sodium carbonate, water / dioxane / 5.5 h / Heating
5: 90 percent / triethylamine, ethyl chloroformate / CH2Cl2 / 1.17 h / Ambient temperature
6: 4.4 g / N-bromosuccinimide, water / tetrahydrofuran / 20 h / Ambient temperature
7: 2.24 g / aq.potassium hydroxide / dioxane / 0.25 h / Ambient temperature
8: lithium di-isopropylamide / tetrahydrofuran / 1.) -75 deg C, 15 min, 2.) -70 deg C, 3 h
With
potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; water; sodium methylate; chloroformic acid ethyl ester; sodium carbonate; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; benzene;
