(1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate

Base Information

• Chemical Name: (1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate
• CAS No.: 256433-53-1
• Molecular Formula: C₁₁H₁₇N₃O₃
• Molecular Weight: 239.274
• Mol file: 256433-53-1.mol

Synonyms:

Chemical Property of (1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate

There total 4 articles about (1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H17ClO3 → (1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate (256433-53-1)

Guidance literature:

With sodium azide; In dichloromethane; water; at 0 ℃; for 1h;

DOI:10.1002/(sici)1099-0690(199911)1999:11<2709::aid-ejoc2709>3.0.co;2-h

Reference yield:

[(1R,2R)-2-(Cyclohex-1-enyloxy)-1-methyl-propoxy]-trimethyl-silane (136413-68-8) → (1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate (256433-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Bu₄NF / tetrahydrofuran; CH₂Cl₂ / 1 h

2: Bu₃N / CH₂Cl₂ / 1 h / 0 °C

3: NaN₃ / H₂O; CH₂Cl₂ / 1 h / 0 °C

With sodium azide; tributyl-amine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water; 1: Desilylation / 2: Formylation / 3: Substitution;

DOI:10.1002/(sici)1099-0690(199911)1999:11<2709::aid-ejoc2709>3.0.co;2-h

Reference yield:

(2R,3R)-3-[(cyclohex-1-enyl)oxy]butan-2-ol (147266-53-3) → (1R,2R)-2-[(cyclohex-1-enyl)oxy]-1-methylpropyl azidoformate (256433-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Bu₃N / CH₂Cl₂ / 1 h / 0 °C

2: NaN₃ / H₂O; CH₂Cl₂ / 1 h / 0 °C

With sodium azide; tributyl-amine; In dichloromethane; water; 1: Formylation / 2: Substitution;

DOI:10.1002/(sici)1099-0690(199911)1999:11<2709::aid-ejoc2709>3.0.co;2-h

upstream raw materials:

[(1R,2R)-2-(Cyclohex-1-enyloxy)-1-methyl-propoxy]-trimethyl-silane

(2R,3R)-3-[(cyclohex-1-enyl)oxy]butan-2-ol

trans-2,3-dimethyl-1,4-dioxaspiro[4,5]decane