3-amino-6-isopropxy-2-methylaminopyridine

Base Information

• Chemical Name: 3-amino-6-isopropxy-2-methylaminopyridine
• CAS No.: 172648-43-0
• Molecular Formula: C₉H₁₅N₃O
• Molecular Weight: 181.238
• Mol file: 172648-43-0.mol

Synonyms:

Chemical Property of 3-amino-6-isopropxy-2-methylaminopyridine

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

6-isopropoxy-N2-methylpyridine-2,3-diamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-6-isopropxy-2-methylaminopyridine

There total 3 articles about 3-amino-6-isopropxy-2-methylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-isopropoxy-2-methylamino-3-nitropyridine (172648-42-9) → 3-amino-6-isopropxy-2-methylaminopyridine (172648-43-0)

Guidance literature:

With hydrogen; 10percent Pd/C; In 1,4-dioxane; at 80 ℃; for 5h;

DOI:10.1021/jm990522t

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 3-amino-6-isopropxy-2-methylaminopyridine (172648-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Na₂CO₃ / ethanol / 8 h / 20 °C

2: methanol / 3 h / 20 °C

3: H₂ / 10percent Pd/C / dioxane / 5 h / 80 °C

With hydrogen; sodium carbonate; 10percent Pd/C; In 1,4-dioxane; methanol; ethanol; 1: Amination / 2: Akoxylation / 3: Catalytic hydrogenation;

DOI:10.1021/jm990522t

Reference yield:

6-chloro-N-methyl-3-nitropyridin-2-amine (33742-70-0) → 3-amino-6-isopropxy-2-methylaminopyridine (172648-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 3 h / 20 °C

2: H₂ / 10percent Pd/C / dioxane / 5 h / 80 °C

With hydrogen; 10percent Pd/C; In 1,4-dioxane; methanol; 1: Akoxylation / 2: Catalytic hydrogenation;

DOI:10.1021/jm990522t

upstream raw materials:

6-isopropoxy-2-methylamino-3-nitropyridine

2,6-dicholoro-3-nitropyridine

6-chloro-N-methyl-3-nitropyridin-2-amine

Downstream raw materials:

(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)methanol

(5-isopropoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol

5-[4-(5-isopropxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione